Synergistic action of steroid hormones and hormone-specific autoantibodies in breast cancer progression

Aim . To study the possible synergistic action of steroid hormones and hormone-specific autoantibodies anti-autoantibodies in conversion ER+/PR+ tumors into ER-/PR- breast cancer patients. Materials Methods Concentrations estradiol (E2) progesterone (Pg) levels idiotypic IgA antibodies (IgA 1 -E2 -Pg) as well anti-idiotypic IgG (IgG 2 were studied serum 979 patients (432 with stage 547 stages 2-4) by means enzyme-linked immunosorbent assay. E2 Pg receptors phenotype (ER/ PR) was determined using immunohistochemistry. Results Simultaneous increase associated elevated concentration (p = 0.007) On contrary, concurrent -Pg и -Pg, lowered 0.04). The frequency low high 2-4 than following cases: 1) regardless 0.004); 2) 0.002); 3) (р < 0,001); 4) E2, Pg, 0,001). In other combinations anti-antibodies, there have been no differences between ascending cancer. Conclusion We for first time found a on patients, tumor receptor conversion.